Derivative of nitrofuran used as an antibacterial medicine (trade name Macrodantin) effective against a broad range of Gram-positive and Gram-negative bacteria; used to treat infections of the urinary tract.
However, there have been concerns regarding decreased nitrofurantoin efficacy with renal insufficiency.
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Now, with nitrofurantoin, that thought experiment is playing out in real life.
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The antibiotic nitrofurantoin is transported against an electrochemical gradient into milk.
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From inhibition studies, the apparent affinity of this transporter for nitrofurantoin is 50 microM.
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The acute reaction to nitrofurantoin is believed to be mediated by an immune mechanism.
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A chronic reaction associated with long-term treatment with nitrofurantoin has also been reported and causes irreversible pulmonary fibrosis.
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Methods: Five lactating female rats received steady-state intravenous infusions of nitrofurantoin with and without the broad-based inhibitor dipyridamole.
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Despite the known pulmonary side effects of nitrofurantoin, there is no report of this toxicity occurring in pregnant patients.
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Acute pulmonary reactions to nitrofurantoin are an uncommon side effect of therapy and can cause minor or life-threatening pulmonary dysfunction.
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The manufacturer is called Nostrum Laboratories, and the drug for which it hiked the price-bymore than 400 percent-iscalled nitrofurantoin.
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In our experience over the past three decades, nitrofurantoin has been safe and effective in treating AUC in hospitalized adults with renal insufficiency.
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Nitrofurantoin is on the World Health Organization's list of essential medicines.
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Nitrofurantoin prescriptions decreased and those of fluoroquinolones increased with increasing age.
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Nitrofurantoin is commonly used to treat urinary tract infections during pregnancy.
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Nitrofurantoin active transport was significantly inhibited by complete sodium replacement.
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The CMA said the investigation had focused on the capsule form of Nitrofurantoin rather than tablets or liquid versions.