Meanings of nonfunctional mutants in inglês

Rescuing the nonfunctional mutants could provide a novel way to treat the related disorders.

Finally, when coexpressed with the wild type, the nonfunctional mutants could also influence the receptor function.

Interestingly, the function of most of these nonfunctional mutants could be rescued by a7nAChR positive allosteric modulator PNU-120596 and agonist-PAM 4BP-TQS.

Second, nonfunctional mutants in three important coupling loops (loop 2, loop 7, and the M2-M3 linker) could be rescued by a gating mutant.