Significados de nuclear hormone em inglês

They act through a family of ligand-activated transcription factors, the nuclear hormone receptors.

PPARs are a family of nuclear hormone receptors belonging to the steroid receptor superfamily.

The ubiquitin-proteasome pathway regulates the turnover of many nuclear hormone receptors, such as the estrogen receptor.

Csn2 also interacts with and regulates a subset of nuclear hormone receptors and is considered a novel corepressor.

The mechanism of transcriptional repression by nuclear hormone receptors, especially in the presence of the ligands, is largely unknown.

LTi cells express the nuclear hormone receptor RORγt, which also directs the expression of the proinflammatory cytokine interleukin-17 in T cells.

An increase in the abundance and activity of the nuclear hormone receptor PPARγ, a repressor of Smad-mediated transcription, contributed to this response.

The nuclear hormone receptor liver X receptor (LXR) is induced by insulin and is a key regulator of lipid metabolism.

The orphan nuclear hormone receptor gene daf-12 in Caenorhabditis elegans plays a key role in the regulation of development and determination of adult longevity.

One likely target for such a hormone is DAF-12, an orphan nuclear hormone receptor that mediates these developmental decisions and also influences adult lifespan.

Moreover, macrophages are known to regulate lipid metabolism via multiple members of the nuclear hormone receptor family, including the retinoid X receptors (RXR).

A present focus is to dissect the consequences of clock disruption on modulation of nuclear hormone receptor signaling and on posttranscriptional regulation of intermediary metabolism.

Rev-erbβ is a heme-binding nuclear hormone receptor that represses a broad spectrum of target genes involved in regulating metabolism, the circadian cycle, and proinflammatory responses.

The therapies are targeted against the Liver X Receptor, a nuclear hormone receptor implicated in a variety of cardiovascular and metabolic disorders, the company said.