1
Recent studies have implicated this nuclear receptor in numerous aspects of oncogenesis.
2
Their lineage specification is regulated by the orphan nuclear receptor RORγt.
3
They function through the glucocorticoid receptor, a member of the nuclear receptor superfamily.
4
However, other nuclear receptor ligands are modifiers of endometrial differentiation leading to successful pregnancy.
5
An important step in steroid receptor action is the recruitment of nuclear receptor coactivators.
6
PPARgamma is a transcription factor of nuclear receptor superfamily, involved in the regulation of inflammation.
7
Rev-erba is a nuclear receptor that links circadian rhythms to transcriptional control of metabolic pathways.
8
The nuclear receptor PPARalpha is activated by drugs to treat human disorders of lipid metabolism.
9
BBI-6000 is a retinoic acid-related orphan nuclear receptor gamma antagonist, which is develops for psoriasis.
10
However, the exact mechanisms by which nuclear receptor-cofactor interactions result in tissue-specific gene regulation are unclear.
11
From these studies an elegant and complex model of nuclear receptor transcription regulation has been developed.
12
Preclinical data suggest that antagonists of this nuclear receptor may enhance the activity of anticancer therapy.
13
PPARγ is a nuclear receptor that modulates inflammation.
14
Sites A and C bind various members of the nuclear receptor superfamily including the liver-enriched factor HNF-4.
15
Recruitment of transcriptional coactivators following ligand activation is a critical step in nuclear receptor-mediated target gene expression.
16
This chapter demonstrates the utility of high-throughput microscopic analyses of nuclear receptor and nuclear receptor coregulator function.
