Significados de null mutation em inglês

Methods: Mice with a null mutation of Elf3 were generated through targeted gene disruption.

Genotyping of non-human primates indicates that the 577X null mutation has likely arisen in humans.

The effects of the null mutation are more severe than the effects of the C282Y mutation.

A null mutation of Hhex results in a failure to form the liver bud and embryonic lethality.

Mice homozygous for an Ikaros null mutation display distinct defects in the development of fetal and adult lymphocytes.

In this report, the biology of PLP-A has been investigated by generating mice with a PLP-A null mutation.

We investigated the in vivo function of GABP by generating a null mutation in the murine Gabpalpha gene.

To test this model, we cloned the gene for the S. cerevisiae guanosine diphosphatase and constructed a null mutation.

When a null mutation was present, 25% of the tumors were associated with distant metastases at initial diagnosis.

Phenotypic comparison of this null mutation with a severe dominant-negative Ikaros mutation identifies molecular redundancy in the postnatal hemolymphoid system.

The tg is a typical null mutation due to the insertion of a transgene into the promoter region of MITF gene.

The mouse has a null mutation that results in no detectable serum biotinidase activity or cross-reacting material to antibody prepared against biotinidase.

Male mice, but not female mice, with a null mutation of Mras displayed persistent mechanical allodynia in a model of inflammatory pain.

As a consequence of inappropriate calcineurin activation, mice with a null mutation in calsarcin-1 showed an excess of slow skeletal muscle fibers.

Because the c-jun- null mutation is early embryonic lethal, thereby hindering a genetic analysis, we used the Cre-lox system to conditionally delete this gene.

In this study, we report on the in vivo effects of the alpha5- null mutation on cell proliferation and survival, and on mesodermal development.