Significados de polygenic risk em inglês

Cognitive impairment and apathy were associated with reduced polygenic risk score for intelligence.

This paper uses polygenic risk scores to explore the possibility of overlapping genetic factors.

Caution is indicated in interpreting studies building on polygenic risk scores without replication sample.

We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity.

Linear approaches, including linear regression and task-specific polygenic risk scores, were employed for comparison.

Unweighted and weighted polygenic risk scores and CBC risk were modeled using conditional logistic regression.

Second, polygenic risk scores for TL show a positive association with medial prefrontal cortex activation.

These findings may lead to improved stratification of Asian patients and controls based on polygenic risk scores.

A polygenic risk score (PRS) was constructed for each survivor using 170 established common risk variants.

Here, we propose a polygenic risk prediction method that does not require explicitly modeling any underlying genetic architecture.

Results: We found that the polygenic risk score for type 2 diabetes was not statistically significantly associated with prostate cancer.

Objective: Utilizing polygenic risk prediction, we aim to identify the phenome-wide comorbidity patterns characteristic of PCOS to improve accurate diagnosis and preventive treatment.

This highlights the necessity of considering continuum models in studying the aetiology of autism spectrum disorder using polygenic risk scores and multimodal neuroimaging.

We are at the cusp of predicting disease risk for some disorders by means of polygenic risk scores integrated with classical epidemiological risk factors.

For each participant, we calculated a polygenic risk score derived from up to 57 common DNA sequence variants previously associated with coronary heart disease.

The type 2 diabetes genetic risk profile was characterized by a 68-variant polygenic risk score weighted by published effect sizes.