However, its development is plagued by poor aqueous solubility resulting in poorbioavailability.
2
The only disadvantage that it suffers is of low aqueous solubility and poorbioavailability.
3
Combined, these factors are known to contribute to reduced ocular residence time and poorbioavailability.
4
The majority of anticancer agents are toxic to normal cells, have poorbioavailability, and lack in vivo stability.
5
The poor results obtained with P in this study might be related to its poorbioavailability after oral administration.
6
Peptides, although high efficacy and specificity in their physiological function, usually have low therapeutical activities due to their poorbioavailability when administrated orally.