These aberrant changes are observed most prominently in medial temporal and prefrontallobe regions.
2
Background: Lesion and neuroimaging studies suggest that left prefrontallobe dysfunction is pathophysiologically linked to depression.
3
Recently, the ROCF has been a useful tool for measuring executive function that is mediated by the prefrontallobe.
4
Variability in COMT activity is related to a Val158Met polymorphism that has been implicated in prefrontallobe cognitive and neuropsychiatric function.