1
Purpose: Ciliopathies are highly heterogeneous clinical disorders of the primary cilium.
2
Bexarotene was identified and validated as a positive regulator of the primary cilium.
3
The primary cilium originates from the mother centriole and participates in critical functions during organogenesis.
4
WDR60 encodes a protein thought to play a role in the primary cilium's intraflagellar transport machinery.
5
We hypothesized biallelic disruption of a gene leading to a defect related to the primary cilium.
6
PKD arises from abnormalities of the primary cilium, a sensory organelle located on the cell surface.
7
In the mutant embryonic fibroblasts, we found mild defects in cell proliferation and primary cilium formation.
8
Calcium signaling within a primary cilium has never been directly visualized and has therefore remained a speculation.
9
Once overlooked as an evolutionary vestige, the primary cilium has recently been the focus of intensive studies.
10
The base of the primary cilium contains a zone of condensed membranes whose importance is not known.
11
Transition fibers (TFs) regulate cilia gating and make the primary cilium a distinct functional entity.
12
As the primary cilium coordinates several signaling pathways essential for odontogenesis, ciliary defects can interrupt the latter process.
13
Recognized as the cell's antenna, primary cilium functions as a signaling hub for many physiologically and developmentally important signaling cascades.
14
Conversely, inhibition of fatty acid synthesis in highly lipogenic human prostate cancer cells restored the formation of the primary cilium.
15
It is thus proposed that the cELV as a nanocompartment within a primary cilium plays an important role in cardiovascular functions.
16
MAL, therefore, is crucial for the proper condensation of membranes at the ciliary base, which is required for efficient primary cilium extension.
