Our data showed that somatosensory cortical ischemia significantly increased the susceptibility to PTZ-induced seizure.
2
KA induced seizure in hippocampus is different to that of both CTA and PTZ.
3
Ability of AEDs to protect from tonic extensor was compared in the MES and i.v.PTZ tests.
4
These facts indicate that PTZ stimulates the release of NT resulting in down regulation of NT receptor.
5
The intravenous pentylenetetrazol (i.v.PTZ) seizure test provides threshold dose for induction of seizures in individual animals.
6
These results indicate that it is advantageous to use i.v.PTZ test as an acute seizure model for screening of antiepileptic drugs.
7
In this work, we designed and synthesized a series of new PTZs by decorating the scaffold in an unconventional way, introducing various halogen atoms.
8
Depletion of β-catenin in reactive astrocytes significantly decreased the susceptibility of seizures and the expression of c-Fos induced by PTZ in the ischemic cortex.
9
Our results suggest that PTZ induced seizures over an already existing epileptic background constitutes a reliable and controllable mean for the screening of new AEDs.