These changes continued for several hours after the respiratory capacity had reached its maximum.

And if their respiratory capacity was too depressed, they would just stop breathing, Lindsay said.

HSPCs also displayed a decrease in mitochondrial oxygen consumption linked to ATP production and basal respiratory capacity.

Ch25h deficiency results in cholesterol-dependent reduced mitochondrial respiratory capacity and release of mitochondrial DNA into the cytosol.

Using extracellular flux analyzer, we show that in cultured DRG neurons meclizine mitigates hypoxia-induced loss of mitochondrial respiratory capacity.

Pharmacological uncoupling of respiration increased OCR in normoxic cultures to 175% of basal levels, indicating significant spare respiratory capacity.

Aerobic training in these individuals resulted in a marked increase in mitochondrial oxidative respiratory capacity without an appreciable increase in mitochondrial content.

This profile was characterized by a decrease in the spare respiratory capacity that was dependent on fatty acid oxidation (FAO).

The results show that in adult rats, concomitant with increased HOMA index, skeletal muscle mitochondria display higher respiratory capacity and energy efficiency.

Endurance exercise induces adaptive increases in the mitochondrial content and respiratory capacity of skeletal muscle, as well as in myoglobin concentration and capillary number.

Nur77 expression also improved the intrinsic respiratory capacity of isolated mitochondria, likely due to the increased abundance of complex I of the electron transport chain.

Respiratory capacity of mitochondria isolated from RV was measured using oxygraphy.

Metabolic experiments showed decreased spare glycolytic capacity in HD neurons, while maximal and spare respiratory capacities driven by oxidative phosphorylation were largely unchanged.

Respiratory capacity is a measure of mitochondrial fitness and cell ability to meet fluctuating energy demands and therefore, a key determinant of cellular fate.