Recent studies have shown that shorthairpin RNAs (shRNAs) can induce gene-specific knockdowns in two cnidarian species.
6
Cyp11a1 gene silencing was performed with Cyp11a1-targeted shorthairpin RNA.
7
Pain behavioral scores were significantly improved in the shorthairpin Protein Kinase C gamma knockdown CCD animals during optic stimulation.
8
In cell culture, HIF-2a levels were up-regulated or down-regulated by use of expression or shorthairpin RNA recombinant plasmid, respectively.
9
Cell proliferation and cycle were assayed in gastric cancer cells after blocking the hedgehog pathway by lentiviral- shorthairpin RNA knockdown.
10
We further used shorthairpin RNA (shRNA)-mediated interference to assess the effect of 21 mutated genes on HB cell survival.
11
Furthermore, animals treated with NOX2 shorthairpin RNA did not develop sustained AF for up to 12 weeks.
12
Proliferation is increased in neuronal progenitor cells after suppression of p21 using lentivirus expressing shorthairpin RNA against p21.
13
AID inhibition using lentiviral-encoded shorthairpin (sh)RNA in B cells developing in humanized mice resulted in a failure to remove autoreactive clones.
14
We have previously identified a target site in HIV-1 RNA that was particularly accessible to a ribozyme and a shorthairpin RNA (shRNA).
15
Indeed, suppression of Caveolin-1 protein expression in E10 cells using shorthairpin RNAs resulted in a large reduction in P2X7 protein expression.
16
To identify the miR-19 targets responsible for its oncogenic action, we conducted a large-scale shorthairpin RNA screen for genes whose knockdown can phenocopy miR-19.