Significados de significant loci em inglês

In the Finland study, we identify several new significant loci that other methods do not detect.

Cross-trait analysis identified 38 genome-wide significant loci, including 7 novel shared loci.

We identified 2 genome-wide significant loci of Hsa12 and Hsa15 in genome-wide linkage analysis.

Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses.

Although a genetic basis of depression has been well established in twin studies, identification of genome-wide significant loci has been difficult.

Objectives: To identify novel genome-wide significant loci for PD in Asian individuals and to compare genetic risk between Asian and European cohorts.

Genetic mapping identified two significant loci, both distinct from those observed for BMD at maturity-implyingthat different genes regulate skeletal growth vs. remodeling.

The effect of the most significant single-nucleotide polymorphism at all genome-wide significant loci on serum urate was added to create a genetic urate score.

Moreover, we validated 2 of 3 of the significant loci examined by adenoviral overexpression of the genes in mice.

From a total of 20 independent genome-wide significant loci, 13 loci replicated of which 8 were novel for depression.

We used a modular approach to identify the most significant loci associated with asthma by combining silhouette statistics and physical distance method with cluster-adapted thresholding.

Genome-wide CNV breakpoint association showed not only significant loci for genetic generalized and developmental and epileptic encephalopathy patients but also for lesional focal epilepsy patients.

Eleven genome-wide significant loci were identified; 2 of these loci were novel (SV2C and WBSCR17) and 9 were previously found in Europeans.

In total, 19 genes contained variants associated with estimated GFR or the urinary albumin-to-creatinine ratio of which 16 mapped into previously reported genomewide significant loci.

A combined stage 1 and 2 meta-analysis identified 66 additional genome-wide significant loci (13, 35, and 18 loci in European, African, and trans-ancestry, respectively).

In our GWAS results, we find that at significant loci the peak markers explained on average between 20 and 40% of variation in the metabolites.