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The gene is disrupted in six patients with X;autosome translocations or submicroscopic deletions; nine patients had point mutations.
3
This is the first report of a live born girl with an X-autosome translocation involving the ZIC3 region.
4
Methods: We report mapping of novel breakpoints of X;autosome-balanced translocations and interstitial deletions and a review of published X chromosome rearrangements.
5
The human Y chromosome, transmitted clonally through males, contains far fewer genes than the sexually recombining autosome from which it evolved.