1
Main outcome measure: Symptoms of lifetime MD as assessed at personal interview.
2
I love English archetypes: public schoolboy, thirties, MD of his father's company.
3
Therefore, MIS may be a safe alternative to open surgery for MD.
4
Twenty-three cases had directly comparable areas of PD versus MD or WD.
5
Diagnosis of MCI was made according to the MDS criteria level II.
1
Strikingly, this amino acid alteration is the same as that seen in the mk mouse.
2
The corporation's job was done: MK was an economic and popular success.
3
MK: My approach is to always find something special, but still approachable.
4
MK opened offices in Japan and San Francisco to woo foreign companies.
5
Thus, our findings defined a role for LOX-PP in reducing MK ploidy.
1
Our investigations revealed a MNK-controlled mechanism acting on mTORC2-AKT.
2
Herein, a structure-based virtual screening approach was performed to identify potential MNK inhibitors from natural products.
3
Compound 23 is the first highly selective dual MNK inhibitor targeting dysregulated translation being assessed clinically.
4
The hit compounds display activity in Mnk biochemical and cellular assays, including acute myeloid leukemia progenitors.
5
MNK-795 would have to be taken only once a day unlike other generic combinations in the market.
1
Mutations in ATP7A can lead to the usually lethal Menkes disease.
2
Menkes disease is a very rare X-linked copper metabolism disorder that results from an ATP7A gene mutation.
3
Rapid diagnosis of Menkes disease and early start of copper therapy is critical for the effectiveness of treatment.
4
With the advent of subcutaneous copper-histidine therapy, the early diagnosis of Menkes disease becomes of utmost importance for patients' prognosis.
5
Menkes disease is an X-linked recessive inherited disease caused by pathogenic variants in ATP7A, which leads to profound copper deficiency.
1
The neuropathologic abnormalities in three new cases of Menkes' kinky hair disease are described.