Significados de synaptic pruning em inglês

However, the molecular mechanisms underlying C1q-controlled synaptic pruning are mostly unknown.

Underused connections are later eliminated, and this elimination process, called synaptic pruning, is highly dependent upon experience.

These molecules may then contribute to synaptic pruning, damage and loss, while TNFalpha can induce neuronal apoptosis and injury.

Importantly, abnormalities in C4A and other complement molecules have been associated with synaptic pruning abnormalities that occur during neurodevelopment.

We propose that this change in sleep regulation is caused by the synaptic pruning that occurs during adolescent brain maturation.

Our results unveiled that C1q label-based synaptic pruning is triggered by and directly linked to apoptotic-like processes in the synaptic compartment.

The classical complement cascade, a key component of innate immune pathogen defence, mediates synaptic pruning by microglia during early postnatal development.

The findings suggest that mental stimulation in early life increases the extent to which synaptic pruning occurs in the lateral temporal lobe.

In the central nervous system, however, recent studies have revealed that complement also has essential roles in synaptic pruning, neurogenesis, and neuronal migration.

Synaptic pruning reduces the volume of tissue in the cortex.