1
Given that numerous oncogenes transform cells by providing cell survival function, we hypothesized that Wnt signaling may inhibit apoptosis.
2
Genetic studies suggest that the E5 protein may transform cells by influencing the activity of cellular proteins involved in growth regulation.
3
The viral early protein, T-antigen, which possesses the ability to transform cells of neural origin, is highly expressed in the tumor cells.
4
Truncations or mutations that disrupt the negative regulatory domain (NRD) of the Myb protein confer an increased ability to transform cells.
5
Expression of the viral protein, T-antigen, which possesses the ability to transform cells of neural origin, has been detected in human CNS tumors.
6
Altering the balance of MYC protein levels at the level of transcription, protein stability, or turnover is sufficient to transform cells to a tumorigenic phenotype.
7
In pathological settings such as cancer, members of the Bcl-2 gene family are able to synergize with oncogenes and tumor suppressor genes to transform cells.
8
Epstein-Barr virus (EBV) was the first human tumor virus being discovered and remains to date the only human pathogen that can transform cells in vitro.
9
The tumorigenic potential of spontaneously transformed cells was investigated in nude mice.
10
In nude mice, spontaneously transformed cells formed malignant tumors expressing GIST markers.
11
HPV- transformed cells actively instruct their microenvironment, promoting chronic inflammation and cancer progression.
12
Eight candidate markers were identified as differentially regulated in transformed cells.
13
Insertional mutants are created by transforming cells with DNA-containing selectable markers.
14
The roots were incubated on callus-inducing medium to generate transformed cells.
15
However, it remains unknown what happens at the boundary between normal and transformed cells.
16
Most studies on endocytosis have used transformed cells in culture.