Reactivity with polyclonal and monoclonal antibodies suggested that neutralizing epitopes were functionally unaltered on the expressed VP4.
2
Moreover, two amino acid substitutions observed in the VP4 gene were conserved between two or more strain pairs.
3
WIN 52035-2 was found to inhibit the first step of uncoating, release of VP4.
4
The membrane permeability induced by recombinant VP4 was influenced by pH and was comparable to permeability induced by infectious virions.
5
The outer capsid proteins VP4 and VP7 are highly variable and represent the major neutralizing antigens.
1
Three distinct forms of VP3 were identified among the nine human rotavirus strains analyzed.
2
In conclusion, the VP3-ELISA is a sensitive and specific method for detecting antibodies against GPV or MDPV.
3
A 66-year-old man was diagnosed with hepatocellular carcinoma with Vp3 by abdominal enhanced CT.
4
Another mutation in the VP3 protein resulted in altered immunological properties of the isolates, possibly facilitating virus spread in immunized populations.
5
Genetic characterization of the viruses revealed that amino acid 60 of the VP3 region was mutated in all AD P1 isolates.
6
A sequence encoding 171 amino acids covering Bcr-Abl breakpoint was fused to the C-terminal part of VP3 minor protein connecting it to the VP1 capsomeres.