VP22 is believed to have certain functions in viral infection apart from virus assembly.
2
Separate epitopes in VP22 were defined for T-cell clones from each of three patients.
3
These results indicate that fusion of VP22 to an antigen gene may greatly enhance the potency of RNA replicon vaccines.
4
Finally, the transcriptional inhibitory effect of VP22 on other viral promoters was demonstrated by the analysis of beta-galactosidase activities in internal controls.
5
VP22 fusion may enhance the efficiency of non-viral gene delivery when combined with the appropriate therapeutic transgene, target tissue and transfection method.