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These findings suggest that overexpression of ORP150 in mice leads to abetalipoproteinemia with alteration of glucose and lipid metabolism.
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Using a genetic model for abetalipoproteinemia, we show that the uptake of labeled fatty acids into the circulation is dependent on lipoprotein production.
1
We report on the unusual association of a malformation syndrome with mental retardation resembling SLOS and profound hypocholesterolemia related to familialhypobetalipoproteinemia.
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Familialhypobetalipoproteinemia is a well-known dominantly inherited entity in which affected individuals usually are free of symptoms.
We tested the effects of PD166326 on two of the clinically observed STI571-resistant Bcr-abl mutants.
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A fist-size tumor had been removed from the stomach of his patient 12 years earlier, but his doctors had not been abl(...)
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PD166326 is a prototype of a new generation of anti-Bcr-abl compounds with picomolar potency and substantial activity against STI571-resistant mutants.
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Agreed pay cuts and the fact that key customers have signed new, long-term contracts mean that Ireland's largest cash-in- transit company has been abl(...)
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Froggie: u thnk so bc u dont no wot its lik not 2 be abl to talk 2 yr fam NE more
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This has been attributed to the activity of p210bcr-abl tyrosine kinase present in the K562 cells, which is known to suppress drug-induced apoptosis.
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Patients with an isolated ABL of a major epicardial vessel were included.
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However, the mechanisms by which c-Abl may influence B lymphopoiesis remain obscure.
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Previous studies on c-Abl-deficient mice have shown high post-natal mortality and lymphopenia.
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The 2 drugs also exhibited a synergistic effect in targeting BCR-ABL protein.
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The v-Abl oncogene promotes cell cycle progression and inhibits pre-B cell differentiation.
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The kinetics of the BCR-ABL transcript correlated well with the patients' clinical course.
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But first, the ABL has to have its first test fight.
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Real-time quantitative RT-PCR appears to be a useful test for BCR-ABL transcript monitoring.
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Stephen Hawking was a true inspiration to the disabled and abled.
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WASF3 phosphorylation by ABL kinase is essential for its ability to regulate invasion.