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This makes inhibition of PKB signaling pathway a promising strategy for cancer therapy.
2
Experiments were performed in MER-Akt cells to investigate the role of PKB in controlling mTOR.
3
PKB's support will add weight to his candidacy.
4
NU says it communicates regularly with PKB but has no intention of intervening in policy affairs.
5
These results demonstrate that PKB activity in early G1 phase is required to prevent the induction of apoptosis.
1
All of these changes involve long-term activation of the proteinkinaseAkt.
2
The host cells demonstrated increased phosphorylation of major survivor proteinkinaseAKT correlating with reduced toxicity of the mutant in comparison with Sterne.
1
Activation of Akt, or proteinkinaseB, is frequently observed in human cancers.
2
Both agents lowered proteinkinaseB activity, but this was not mediated by inhibiting phosphoinositide 3-kinase.
3
We found a high level of proteinkinaseB (AKT) phosphorylation after 6 h of cold exposure.
4
The Akt ( proteinkinaseB) kinase is a key player in transduction of antiapoptotic and proliferative signals in T cells.
5
A lower level of phosphorylated proteinkinaseB was observed in PFKFB3-knockdown endothelial cells, which was accompanied by a decrease in intracellular lactate.
Использование термина akt на английском
1
The current studies identify a new role for Akt in CNS myelination.
2
Conclusion: The Akt-Caspase 3 signal pathway may be involved in these processes.
3
We compared this effect by Western Blot analysis of Akt protein expression.
4
Moreover, the CG treatment down-regulated the phosphorylation levels of Akt and GSK3β.
5
Methods: Akt-2 expression was analyzed by western-blotting and Q-PCR in cell lines.
6
All of these changes involve long-term activation of the protein kinase Akt.
7
Further, the proapoptotic-like effects were associated with an inhibition of Akt phosphorylation.
8
Targeting MERTK also decreases cell survival and proliferation in an AKT-dependent manner.
9
LID-TRAMP tumors displayed increased levels of GH receptors and increased Akt phosphorylation.
10
The protein expressions of Akt signal pathway were detected by Western blotting.
11
In the presence of S247, the radiation-induced Akt phosphorylation is strongly inhibited.
12
Idelalisib decreased p-Akt in patient samples of ALL with diverse genetic lesions.
13
The downstream signaling target, Akt kinase, was not altered in trained subjects.
14
We also demonstrate that Akt was the downstream molecule regulating cell adhesion.
15
Here we demonstrated that Akt was frequently activated in Barrett esophagus-related adenocarcinoma.
16
Instead, we show a requirement for ILK in integrin receptor-induced Akt activation.