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Results: Behaviorally, atomoxetine led to a significant increase in failed inhibition.
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In general, d-amphetamine increases risk-taking while atomoxetine has produced mixed effects in rats.
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There were no significant improvements while on atomoxetine compared with placebo on primary outcomes.
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There were no serious adverse events related to atomoxetine.
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Effects of d-amphetamine on probabilistic discounting may be biology-dependent and differ from effects of atomoxetine.
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In addition, atomoxetine tended to reduce reaction time variability.
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Adults with narrow-angle glaucoma should not use atomoxetine.
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A total of 921 children and adolescents with ADHD participated in a clinical study of atomoxetine.
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Conclusion: This study demonstrated no increase in the risk of sudden death associated with stimulants or atomoxetine.
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Especially the increased expression of SNAP-25 and GABA-A receptor subunits may indicate additional active therapeutic mechanisms for atomoxetine.
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We found that atomoxetine increased the subject's perceptual sensitivity to discriminate target stimuli regardless of the task contingency.
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In this study, we evaluated dose-dependent effects of d-amphetamine and atomoxetine on probabilistic discounting of Lewis and F344.
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Sudden cardiac death has occurred in children and adults taking atomoxetine; it increases heart rate and blood pressure significantly.
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Although atomoxetine was not effective at improving attention at this dose, its safety and tolerability were similar to other studies.
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We investigated the effects of atomoxetine (80 mg) on error monitoring as a second key component of cognitive control.
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The objective of this animal study was to determine alterations in gene expression patterns in the prefrontal cortex after long-term administration of atomoxetine.