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Microchip electrophoretic separations of neurotransmitters in under 100 s exemplify the good resolution and attomole detection sensitivity of these devices.
2
As low as 0.5 attomoles purified aequorin gave a signal-to-noise ratio of 1.8.
3
Excellent linearity was observed 0.99227-0.99999 and limit of detection values ranged from 63.75 attomoles to 1.21 femtomoles.
4
Microarray signal dynamic range was found to be linear across three orders of magnitude from 4.88 to 5000 attomoles.
5
Modifications were detected at concentrations four orders of magnitude lower than the corresponding parental nucleosides, and as low as 23.01 femtograms, 64.09 attomoles.
6
Complementary chi(3) charge screening studies indicate that the signal originates from 5 x 10(11) strands per square centimeter, or 6 attomoles of surface-bound oligonucleotides.