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We identified the NF-kappa Bsite in the FasL promoter that contributes to such regulation.
2
Both A and Bsites are half-occupied.
3
Herein, we demonstrated that individual mutations within the proximal and distal nuclear factor-k Bsites impaired cytokine-mediated transcriptional activation.
4
Methane molecules in Bsites interact with the side of the phenyl rings through van der Waals interaction.
5
Such kappa Bsites are likely candidates for regulation by p50 homodimers and Bcl-3.
6
The IL-2R alpha enhancer binds NF-kappa B poorly and is only weakly activated by the NF-kappa Bsite alone.
7
Jurkat T cells stably expressing tax contained elevated levels of NF-kappa B that directly bound to the LT-kappa Bsite.
8
This is consistent with a model in which the 3' terminus of the vRNA template binds in the mode Bsite during elongation.
9
Furthermore, we show that the mode Bsite is not needed for initiating transcription in vitro but is required to synthesize a full-length product.
10
The nu1 phosphate band at 960 cm-1 shifts slightly due to carbonate substitution in both A and Bsites.