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PR involved strength and endurance training, and CPT involved lung expansion techniques.
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Despite the grounded forecast, the rains are most certainly welcome in CPT.
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Conclusions: CPT-11 is a very active agent for NSCLC with acceptable toxicities.
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Results: Construct validity of 5C-CPT has been verified by multiple cross-species studies.
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Similar patterns of cellular retention and chemical degradation were observed with CPT.
1
A fourth hit, 9-methoxy-camptothecin, was identified by screening the natural compound library in the absence of verapamil.
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The chemical stabilities of camptothecin and the ring-opened form in aqueous solutions, in plasma and after methanolic extraction, were investigated.
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Irinotecan is a semisynthetic analogue of the natural alkaloid camptothecin which prevents DNA from unwinding by inhibition of topoisomerase I.
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Knowledge of the structure-activity relationships of the parent compound camptothecin has led to the development of effective soluble analogues with manageable toxicities.
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We report here that the release mechanism of free camptothecin from self-assembling drug amphiphiles can be regulated by use of different linker groups.