Here we review the current understanding of glioma cancer stem cell biology.

The ID2 protein supports cancer hallmarks including the cancer stem cell state.

Resistance has been attributed to an acquired or selected cancer stem cell phenotype.

The cancer stem cell (CSC) theory represents a breakthrough in cancer research.

Salinomycin reduced cancer stem cell phenotype and decreased telomerase activity of colorectal cancer cells.

The cancer stem cell model introduces new strategies for the prevention and treatment of cancers.

Indeed, recent studies show that hypoxia and its molecular responses regulate cancer stem cell maintenance.

The role of NIK in the phenotype of cancer stem cell regulation is poorly understood.

That necessary change, however, is also a major source of uncertainty in cancer stem cell research.

However, the existence of a cancer stem cell component in GIST has not been yet established.

The cancer stem cell theory of tumor creation had taken the field of oncology by storm.

This observation may have implications on the bone marrow contribution to the cancer stem cell population.

Long-time critics of the cancer stem cell theory like Johns Hopkins oncologist, Scott Kern, are pleased.

These were assessed for estrogen dependency, steroid receptor expression, cancer stem cell content, and endocrine therapy response.

Moreover, this reprogramming method may provide insights into primordial cell tumour formation and cancer stem cell transformation.

Finally, we confirmed the repressive effect of miR-145 on cancer stem cell properties and EMT in vivo.