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Intriguingly, two carboxylates instead of one mediate ion binding.
2
The route is based on the oxidative rearrangement of 3-arylindole-2-carboxylates.
3
Beta-oxidation of carboxylates takes place both in mitochondria and peroxisomes and in each pathway parallel enzymes exist for each conversion step.
4
Side-chain carboxylates of glutamates and aspartates functionally replace phosphates and thereby generate an overall charge pattern resembling the DNA phosphate backbone.
5
In order to further clarify the physiological role of this enzyme in the degradation of fatty carboxylates, MFP-2 knockout mice were generated.