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Substrate immobilization localizes the DNA and the delivery vector to the cellularmicroenvironment.
2
The mechanics of the cellularmicroenvironment can be as critical as biochemistry in directing cell behavior.
3
This material provides a biomimetic cellularmicroenvironment that can be applied as a three-dimensional platform for cell culture.
4
This indicates the extent to which gene expression profiles are uniquely dependent on hormone-treatment times and the cellularmicroenvironment.
5
Moreover, the natural cellularmicroenvironment in the body can be harnessed for tissue maturation resulting in the tissue regeneration and repair.
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The effects of CO on gene expression can be thus varied, depending on the cellularmicroenvironment and the metabolic pathway being influenced.
7
The invasiveness of glioma cells, a major cause of mortality in malignant brain tumors, is mediated in part by the cellularmicroenvironment.
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In addition, we give examples of the use of microscale technologies for controlling the cellularmicroenvironment in vitro and for performing high-throughput assays.
9
Together, our data strongly support the notion that the mechanical signals from the cellularmicroenvironment influence neuroblastoma differentiation and do so synergistically with RA.
10
Recent single-cell transcriptomic studies revealed new insights into cell-type heterogeneities in cellularmicroenvironments unavailable from bulk studies.
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Overall, this system may be useful for high-throughput screening, single-cell analysis and studies of cell-cell communication, where rapid control of 3D cellularmicroenvironments is desired.
12
Our results are compatible with a model in which recognition of RNA1 and RNA2 for encapsidation occurs sequentially and in distinct cellularmicroenvironments.