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Using a simulated annealing algorithm, CIMO seeks to minimize differences between the optimized and sequenced intensity maps.
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The CIMO algorithm was applied, and the optimized aperture shapes and weights were loaded back into Pinnacle.
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On average, the CIMO algorithm provided a 54% reduction in the number of beam segments as compared with Pinnacle's leaf sequencer.
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The plans sequenced using the CIMO algorithm also provided improved target dose uniformity and a reduced discrepancy between the optimized and sequenced intensity maps.
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For ten clinical intensity maps, comparisons were performed between the CIMO algorithm and the power-of-two reduction algorithm of Xia and Verhey [Med.
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CIMO was observed to mediate its anti-proliferative effect in ER- BC cells by inhibiting the phosphorylation of JAK2 and STAT3 proteins.