1
The SNARE intermediates are biologically important because they serve as targets for fusion regulators and clostridial neurotoxins.
2
Clostridial neurotoxins potently and specifically inhibit neurotransmitter release in defined cell types.
3
Clostridial neurotoxins possess discrete structural domains with distinct pharmacological properties.
4
Clostridial neurotoxins affect mainly the highly regulated fusion of neurotransmitter- and hormone-containing vesicles with the plasma membrane.