Значения термина continual reassessment на английском

We aim to motivate wider use of model-based designs for dose finding, such as the continual reassessment method (CRM).

These include continual reassessment of pain and risk, treatment agreements, compliance monitoring, urine drug screening, documentation, compliance with the law, and patient education.

A continual reassessment approach with a straightforward dose selection criterion using the accumulated data from all patients treated to that point is employed.

Dose escalation was based on the modified continual reassessment method (MCRM), with one patient treated at each minimally toxic dose level.

The continual reassessment method is a recommended dose escalation design for including patients in phase I clinical trials designed to estimate the maximum tolerated dose.

Part 1 uses a restricted 1-stage Bayesian continual reassessment method based on a target dose-limiting toxicity probability of 35%.

Methods: An adaptive, two-stage continual reassessment trial was designed to evaluate the safety of regadenoson (A 2A R agonist) in the setting of lung transplantation.

Model-based approaches proposed to identify the MTD (including the Continual Reassessment Method or CRM) suppose a simple model for the dose-toxicity relation.