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The present results confirm a significant diversity of CoVs circulating in Kenya bats.
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The results demonstrated that the vast majority of SARS-CoVs are sensitive to 80R.
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These Kenya bat CoVs are phylogenetically distant from any previously described human and animal CoVs.
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The low pathogenic CoVs infect the upper respiratory tract and cause mild, cold-like respiratory illness.
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Sequences analysis confirmed that the CoVs from Kenya bats are divergent members of Alphacoronavirus and Betacoronavirus genera.
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We discovered that CovS primarily serves to phosphorylate CovR, thereby resulting in the repression of virulence factor-encoding genes.
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Coronaviruses (CoVs) have caused outbreaks of deadly pneumonia in humans since the beginning of the 21st century.
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Previously, groups had targeted conserved coronavirus proteins as a strategy to generate live attenuated vaccine strains against current and future CoVs.
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This particular development in CoVs has been responsible for the serious outbreaks in the last two decades, and for the present COVID-19 pandemic.