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In currentclamp, large overshooting action potential-like events were observed only after prior hyperpolarizing current injections.
2
Approach: APs were evoked locally by two-electrode currentclamp or at a distance for propagating APs.
3
Individual neurons in the locus coeruleus (LC) were studied in the whole-cell currentclamp.
4
This hyperactive phenotype could be negated by currentclamp and correlated with both membrane resistance and soma area.
5
In currentclamp, hyperpolarizing current steps produced a time-dependent depolarizing sag followed by either a rebound afterdepolarization or an action potential.
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Under currentclamp, block of BK Ca current increased depolarizing membrane potential excursions, raising the average resting potential and producing oscillations.
7
In control mice, currentclamp recordings showed that a-m-5-HT induced a depolarization of V(rest) which was sufficient to suppress burst firing.
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Results: Currentclamp measurements revealed that the photo-activated CS molecule causes a sharp depolarization of about 15 mV.
9
The potencies of P1 purinoceptor agonists were estimated in neurones that were currentclamped to a fixed membrane potential.
10
Currentclamp of 18 channels was performed in silico to elucidate the ionic mechanisms underlying action potential modulation by RPP.
11
In currentclamped horizontal cells, BK Ca channels subdue depolarizing membrane potential excursions, reduce the average resting potential and decrease oscillations.
12
Currentclamp studies of transduced striatal neurons demonstrated an increase in the firing threshold, latency to first action potential and decrease in neuronal excitability.