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TARA regulates CycA protein levels and genetically and physically interacts with CycA to promote sleep.
2
We propose that TARANIS controls sleep amount by regulating CycA protein levels and inhibiting Cdk1 activity in a novel arousal center.
3
Anyone who attended the CYCA at the following times is asked to monitor for symptoms and get a test if they develop symptoms.
4
We report here that there are four cycA transcripts by high-resolution Northern (RNA) blot analysis, and we have mapped 10 5' ends by primer extension.
Использование термина cyclin на английском
1
Purpose: Flavopiridol is the first cyclin-dependent kinase inhibitor to enter clinical trials.
2
The results implicate a putative cyclin-dependent kinase in the control of development.
3
The other three mutants caused phenotypes dependent on the particular cyclin-dependent kinase.
4
This review describes the mechanisms of these new functions of cyclin D1.
5
Tissue from the same 10 patients contained viral cyclin on PCR analysis.
6
Cdc2 is the cyclin-dependent kinase that controls entry of cells into mitosis.
7
D-type cyclin-dependent kinase activities have not so far been detected in mammalian cells.
8
A major determinant of Acm1 stability is phosphorylation at consensus cyclin-dependent kinase sites.
9
The protein level of cyclin E decreased in the cell cycling regulation pathway.
10
No changes were observed in the expression of cyclin D1 protein.
11
This was linked to reduced CHK1 activation, increased cyclin E levels and apoptosis.
12
In contrast, cyclin E expression in Rb-deficient cells is deregulated in two ways.
13
Two of the five mutant alleles produced similar phenotypes for both cyclin-dependent kinases.
14
Nevertheless, none of these cell lines revealed amplification of the cyclin D1 gene.
15
This study was designed to analyze cyclin E expression threshold quantitatively.
16
The activation of estrogen receptor by cyclin D1 is not inhibited by anti-estrogens.