These gene variants may decrease drug tolerance and promote herpes virus reactivation.

Another reason of drug tolerance is the efflux pump of the bacterium.

Persistence, manifested as drug tolerance, represents a significant obstacle to global tuberculosis control.

Phenotypic plasticity is associated with non-genetic drug tolerance in several cancers.

However, patients may fail to respond to treatment and drug tolerance may occur with time.

There was no evidence for drug tolerance or changes in the morphological appearance of the bladder.

We observed a rapid and persistent decline of clinical signs and systemic inflammation and good drug tolerance.

Secondary outcomes included disease control rate at four cycles, best ORR, progression-free survival, overall survival, and drug tolerance.

Alternatively, drug tolerance to toxic effects might have occurred in the subjects, who were all chronic methamphetamine users.

The drug tolerance of the H1975 cell line by 89.5 dropped to 39.2 times.

These results suggest that GlpK phase variation may contribute to drug tolerance, treatment failure, and relapse in human TB.

Often, doses of these drugs must be increased considerably over time as they lose their effectiveness-an indication of drug tolerance.

Mechanisms to explain greater drug tolerance in children and the observation of decreasing maximum tolerated dose ratios with time are discussed.

The two approaches yield a consistent picture that accounts for the phenotypic heterogeneity observed over the course of drug tolerance development.

But again, as her drug tolerance levels increased, she needed to increase the recommended daily dosage from eight to 20 tablets.

In addition, closer monitoring and evaluation activities are needed in the programme to monitor the drug tolerance and to adjust treatment focus.