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We identified candidate pools of epigenetic compounds that improve skeletal muscle structure in dmd mutant zebrafish.
2
Results: We performed a novel chemical-combination screen of a library of epigenetic compounds using the zebrafish dmd model.
3
A commercially available library of epigenetic small molecules was used to treat embryonic-larval stages of dmd mutant zebrafish.
4
Methods: Eight families at risk for DMD were recruited for this study.
5
DMD segment supplies newspaper and magazines to airlines and provides inflight services.
1
Dp71 has also been shown to have roles in various cellular processes.
2
Western blotting of the satellite cell lysate showed a band corresponding to over-expressed Dp71ab.
3
Although Dp71 is comprised of many variants, Dp71 in satellite cells has not yet been studied.
4
The amplified product showed deletion of both exons 71 and 78 in all sequenced clones, indicating monoclonal expression of Dp71ab.
5
Here, the full-length Dp71 consisting of 18 exons from exons G1 to 79 was amplified by reverse transcription-PCR from total RNA of human satellite cells.
Использование термина dystrophin на английском
1
Analysis of dystrophin now allows confirmation of the existence of this disorder.
2
Recent studies suggest that the site specific anchoring depends on the dystrophin complex.
3
In dogs with DMD, you can see the absence of the dystrophin protein.
4
Analysis of DNA revealed a deletion in the 1st third of the dystrophin gene.
5
No dystrophin gene defects were found in our patients, whose average age was 50 years.
6
This disorder represents a new clinical phenotype associated with a deletion in the dystrophin gene.
7
Subsequent dystrophin testing confirmed all of the DNA-based diagnoses.
8
The total dystrophin deficiency leads to DMD while the reduction of dystrophin expression to BMD.
9
The absence of dystrophin protein leads to progressive muscle weakness and wasting, disability and death.
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UT Southwestern Medical Center In DMD dogs treated with CRISPR, levels of dystrophin are restored.
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The reason for the severe cardiomyopathy remains speculative, in the absence of dystrophin data on their heart.
12
Thus, the absence of dystrophin appears to render muscle specifically more susceptible to free radical induced injury.
13
This suggests that lack of sarcolemmal integrity triggers a generally perturbed protein expression pattern in dystrophin-deficient fibres.
14
This large deletion includes the dystrophin gene as well as the region involved in X-linked mental retardation.
15
The drug enables the production of dystrophin.
16
We demonstrate that levels of dystrophin protein restoration, and thus patient response, correlate accurately with the RNA level.