1
For select AR, mitochondria were also smaller as ECM rigidity increased.
2
On some substrates, a-actinin volume increased with cell AR but was not affected by ECM rigidity.
3
Collectively, these results suggest that mitochondrial architecture in cardiac myocytes is strongly influenced by cell shape and moderately influenced by ECM rigidity.
4
In this study, we tested the hypothesis that cell aspect ratio (AR) and ECM rigidity regulate the architecture of the mitochondrial network in cardiac myocytes.