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In contrast, T-705 acts as a potent and GTP-competitive inhibitor of the viral polymerase.
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T-705 (favipiravir) is a new antiviral agent in advanced clinical development for influenza therapy.
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Influenza virus-infected cell cultures were exposed to T-705 or ribavirin during single or serial virus passaging.
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This mutagenic effect is 2-fold higher for T-705 than for ribavirin.
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Whereas neuraminidase inhibitors slow down viral replication, T-705 is a viral RNA polymerase inhibitor which prevents viral replication.
Usage of favipiravir in английском
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FabiFlu's price is significantly lower than versions of favipiravir in other countries, the company added.
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The first results for brincidofovir are expected in February and for favipiravir in late March.
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T-705 (favipiravir) is a new antiviral agent in advanced clinical development for influenza therapy.
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These unique anti-viral profiles will make favipiravir a potentially promising drug for specifically untreatable RNA viral infections.
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The antiviral favipiravir from Japan's Toyama Chemical was developed to fight RNA viruses such as the new coronavirus.
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Both are based on favipiravir, which was developed in Japan and is widely used there as the basis for viral treatments.
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Already available generically in many countries under the name favipiravir, the drug has been approved to treat COVID-19 in India and Russia.
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Avigan, originally developed as an emergency flu drug and known generically worldwide as favipiravir, has been approved in India and Russia to treat COVID-19.
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Its antiviral effect is attenuated by the addition of purine nucleic acids, indicating the viral RNA polymerase mistakenly recognizes favipiravir-RTP as a purine nucleotide.
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MSF says the trial so far suggests the most vulnerable patients who are most likely to die from the disease don't benefit from favipiravir.
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Avifavir, known generically as favipiravir, was first developed in the late 1990s by a Japanese company later bought by Fujifilm as it moved into healthcare.
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Hyderabad-based Dr Reddy's also has tie-ups with global firms to sell coronavirus treatments remdesivir and favipiravir in India besides its partnership for the Sputnik-V vaccine.
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We used supportive treatment with intravenous fluids, broad-spectrum antibiotics, and experimental treatments with convalescent plasma from two survivors of Ebola virus disease and high-dose favipiravir.
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SARS-CoV-2 PCR tests were negative on days 17 and 18 of favipiravir therapy, and the patient was discharged without residual disease on the final CT.
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Favipiravir was originally developed by Japan's Fujifilm Holdings Corp under the brand name Avigan for treating influenza.
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Favipiravir would need government approval for full-scale use on Covid-19 patients, since it was originally intended to treat flu.