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Objective: To examine longitudinally the adaptive behavior patterns in fragile X syndrome.
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Fragile X Syndrome is the most common form of hereditary mental retardation.
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At the time when demethylation did occur, fragile X expression was not affected.
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Fragile X syndrome results from mutations in the X-linked FMR1 gene.
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Fragile X is the most common known genetic cause of autism.
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These results strongly indicate that DNA demethylation is not involved in fragile X expression.
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Experiments were performed to determine the role of DNA demethylation in fragile X expression.
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Background: Fragile X syndrome is the most common monogenic cause of intellectual disability and autism.
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Mice have been bred to exhibit everything from Alzheimer's to obesity to fragile X syndrome.
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The fragile X syndrome of mental retardation is one of the most common genetic diseases.
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It is possible that longer-term treatment would result in further improvement in these fragile X phenotypes.
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FMRP belongs to a family of proteins that includes the Fragile X Related Proteins or FXRPs.
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Under conditions where 5-azacytidine was found to inhibit fragile X expression, no DNA demethylation was observed.
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Fragile X syndrome (FXS) is a leading genetic cause of intellectual disability and autism.
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Females with fragile X syndrome did not show a discernible pattern of developmental strengths and weaknesses.
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Well, in Fragile X, the consequence is-orwas, before we learned to repair it-moderatemental retardation.
