Carbohydrate metabolic disorder that is characterised by abnormally low levels of glucose-6-phosphate dehydrogenase (abbreviated G6PD or G6PDH)
1 The effect of G6PD deficiency on risk of pneumococcal disease is undefined.
2 Quantitative diagnostic tests for G6PD deficiency are complex and require sophisticated laboratories.
3 Conclusion: Access to POC testing for G6PD deficiency in Ghana was poor.
4 Erythrocyte G6PD deficiency is the most common worldwide enzymopathy.
5 Testing for G6PD deficiency is mandatory before tafenoquine prescription.
6 We evaluated the geographical accessibility to POC testing for G6PD deficiency in Ghana, a malaria-endemic country.
7 Rapid diagnostic tests capable of diagnosing G6PD deficiency are now available, but these are not used widely.
8 We hypothesized that G6PD deficiency increases pneumococcal disease risk and that this effect is dependent upon malaria.
9 Conclusions: Our data demonstrate that G6PD deficiency increases risk of pneumococcal bacteremia in a manner dependent on malaria.
10 We also obtained the geolocated data of all public hospitals providing G6PD deficiency testing services in the region.
11 For this reason it is imperative to identify individuals with G6PD deficiency prior to administering these anti-malarial drugs.
12 To assess the overall effect of G6PD deficiency trait, deficiency alleles found across all three loci were pooled.
13 Qualitative G6PD tests are sufficient for diagnosing G6PD deficiency in males.
14 At the population level, the impact of G6PD deficiency on invasive pneumococcal disease risk in malaria-endemic regions is substantial.
15 These observations may help to explain the discrepancy in some published association studies involving G6PD deficiency and uncomplicated malaria.
16 Therefore, patients with severe forms of G6PD deficiency may present impaired NADPH oxidase activity and become susceptible to recurrent infections.
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