In this study administration of yeast-derived vaccine yielded better results than plasma-derived vaccine when administered by the intradermal route.

A study of the safety and immunogenicity of plasma-derived and yeast-derived recombinant hepatitis B vaccines administered by the intradermal route is reported.

There is recent evidence that the clinically less often used intradermal route is effective; in cases even superior to the conventional subcutaneous or intramuscular route.

Intradermal route was effective not only for pre-exposure but also for booster vaccination.