Preclinical studies and human trials suggest that intravenous lidocaine may confer protection in the setting of neurologic injury.

The findings of this meta-analysis indicate that prophylactic intravenous lidocaine is effective at preventing FIC in both adults and children.

Intravenous lidocaine infusion did not significantly reduce postoperative pain after tonsillectomy in the dosage used.

Conclusions: Intravenous lidocaine administered during and after cardiac surgery did not reduce postoperative cognitive decline at 6 weeks.