The increase in lacrimation is likely due to an increase in cool cell activity.

Methods: A 6-month-old child with diagnosed PR sequence presented to us with dysfunctional lacrimation present since birth.

Conclusions: These studies indicated that low concentrations of menthol can increase lacrimation via TRPM8 channels without evoking nocifensive behaviors.

Salivation, lacrimation, urination, and defecation.

In contrast, mild cooling of the ocular surface has been reported to increase lacrimation via activation of corneal cool primary afferent neurons.

From this region, major control of lacrimation is carried through projections to preganglionic parasympathetic neurons located in or around the superior salivatory nucleus.