Parallel medicinal chemistry efforts based on this lead resulted in compound 1.

The importance of γ-keto sulfones in medicinal chemistry and organic synthesis is known.

No medicinal chemistry effort has been made to identify LbSOD inhibitors.

Therefore, the targeting of i-motif DNA is an emerging research area in medicinal chemistry.

The medicinal chemistry program elucidated structure-activity relationships within the series.

Overall, the described procedure should facilitate the broader use of copper-catalyzed trifluoromethylation in medicinal chemistry.

The medicinal chemistry strategy and biological properties are described.

Quantitative structure-activity relationship modeling is one of the major computational tools employed in medicinal chemistry.

Molecular recognition and chemical modification of DNA are important in medicinal chemistry, toxicology, and biotechnology.

Thioureas and their derivatives are of considerable significance and are privileged scaffolds in medicinal chemistry.

This review is an attempt to compile the medicinal chemistry of various synthesized CA-4 analogs.

Effective computational prediction of complex or novel molecule syntheses can greatly help organic and medicinal chemistry.

A structure-based and parallel medicinal chemistry approach was applied to the synthesis of novel tubulysin analogues.

Educational activity and setting: A student-pharmacist and medicinal chemistry faculty member collaborated to reboot a SP-APPE.

Extensive medicinal chemistry optimization afforded the best analogue with an MIC of 90 nm against Mtb.

She is chair of organic chemistry and director of medicinal chemistry at the University of Auckland.