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There was no increase in resistance to methylmethanesulfonate and N-hydroxyethyl-N-chloroethylnitrosourea.
2
In primary cell cultures, heterozygous cells also display reduced proliferation rates and moderate sensitivity to methylmethanesulfonate.
3
Bleomycin and methylmethanesulfonate also induced strand cleavage in a synthetic oligonucleotide duplex even without thermal treatment.
4
We also analyzed sensitivity to methylmethanesulfonate, observing little dependence of resistance on MGMT and persistent variability in cytotoxicity in the presence of O6-BG.
5
In comparison with data obtained with the methylating agent methylmethanesulfonate we further conclude that the assumption of DNA adducts being oversensitive biomarkers is adduct-specific.