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Basal bodies (BBs) nucleate and position motilecilia at the cell cortex.
2
To optimize directed hydrodynamic flow, motilecilia are organized and oriented into a polarized array.
3
We discovered that motilecilia on airway epithelial cells have HH signaling proteins, including patched and smoothened.
4
In several vertebrate embryos, motilecilia generate an asymmetric fluid flow that is necessary for normal LR development.
5
Immunohistochemical staining for dynein axonemal heavy chain 5 discriminated multiple motilecilia from primary cilia in human FT.
6
Basal bodies comprise nine symmetric triplet microtubules that anchor forces produced by the asymmetric beat pattern of motilecilia.
7
The directional flow generated by motilecilia and flagella is critical for many processes, including human development and organ function.
8
Cilia are cell surface organelles with key roles in a range of cellular processes, including generation of fluid flow by motilecilia.
9
We assessed the relative distribution of primary cilia on secretory cells and motilecilia on multiple ciliated cells by immunofluorescence and immunohistochemical staining.
10
In motilecilia, dynein ATPase motor proteins generate sliding motions between adjacent microtubules, which are integrated into a well-orchestrated beating or rotational motion.
11
Motilecilia and flagella are highly conserved organelles that play important roles in human health and development.
12
Motilecilia generate directed hydrodynamic flow that is important for the motility of cells and extracellular fluids.
13
Motilecilia polarization requires intracellular anchorage to the cytoskeleton; however, the molecular machinery that supports this process remains elusive.
14
Motilecilia are restricted to specific populations of well-differentiated epithelial cells, including those in the airway, brain ventricles, and oviducts.