We explored the possibility that penicillintolerance could explain this phenomenon.
2
Transconjugants carrying high-level resistance to kanamycin exhibited characteristics of penicillintolerance.
3
A total of 30 clinical isolates of group B streptococci were studied for penicillintolerance in vitro.
4
This method promises to be of value in the further characterization and understanding of penicillintolerance in vitro and in vivo.
5
These findings suggest that the genetic basis for penicillintolerance is related to that for high-level resistance to kanamycin in group A streptococci.
6
Of 189 streptococcal isolates tested by the gradient replicate plate method for penicillintolerance, 18 (10%) were tolerant.
7
Penicillintolerance was recognized by the gradient-replicate plate method and by time-kill experiments with penicillin concentrations of 16 times the minimal inhibiting concentrations.