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In this study we investigated how PFV Gag subnuclear distribution might be regulated.
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Conclusions: Varying degrees of PFV seem to be a frequent cause of unilateral congenital cataracts.
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For each group, the greatest improvements in NPC and PFV were achieved during the first 4 weeks.
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Only the OBVAT group continued to show significant improvements in PFV at weeks 8 and 12.
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It is therefore suggested that PFV cores bear at least three separate nuclear localization signals, one in Gag and two in Pol.
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This suggests that unilateral PFV may in fact be a bilateral, asymmetric process, but the clinical significance of these subtle findings is not known.
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Absence of intercellular spreading in vivo was further confirmed using a sensitive luciferase activity assay based on transactivation of the PFV long terminal repeats.
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Conclusions: The rate of improvement is more rapid for clinical signs (NPC and PFV) than for symptoms in children undergoing treatment for CI.
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Characteristic features of PFV were found in 75% of group I eyes, in 8% of group II eyes, and in 67% of group III eyes.