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We identified cDNAs encoding an active mono-oxygenase that is highly homologous to mammalian PHM.
2
PHM is the rate-limiting enzyme for C-terminal alpha-amidation, a specific and necessary modification of secretory peptides.
3
Horton Inc DHI.N and rival PulteGroup Inc PHM.N reported quarterly profits in April that topped estimates.
4
These deficits were partially reversed within 24 h by a single PHM induction in the adult stage.
5
The mechanistic and structural insight gained from the PHM structures can be directly extended to dopamine beta-monooxygenase.
6
These structures strongly suggest that the PHM reaction proceeds via activation of substrate by a copper-bound oxygen species.
7
PHM mutants lack PHM protein and enzyme activity; most null animals die as late embryos with few morphological defects.
8
The current state of pediatric hospital medicine (PHM) educational scholarship dissemination via journal publication has not been well described.
9
The weak results come a day after rivals Ryland Group Inc RYL.N and Pulte Homes Inc PHM.N also reported second-quarter losses.
10
Natural and synthetic PHM hypomorphs revealed phenotypes that resembled those of animals with mutations in genes of the ecdysone-inducible regulatory circuit.
11
"Mmm phm!" Her thin face whitens, and her wide eyes turn to Indra for help.
12
The Drosophila PHM gene displays an organization of exons that is highly similar to the PHM-encoding portion of the rat PAM gene.
13
Given this structure, it is likely that dioxygen is directly involved in the electron transfer and hydrogen abstraction steps of the PHM reaction.
14
These studies strongly indicate that the reductive phase and catalytic phase ET pathways are different and suggest a bifurcated ET pathway in PHM.
15
The present study uses CO as a surrogate for oxygen to probe how substrate binding triggers oxygen activation in peptidylglycine monooygenase (PHM).