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Substitution of Ala for Phe at position 5 conferred 300-fold selectivity against NaV1.4.
2
Return to position 5, then position 2 and then position 1.
3
For this purpose some thiazolidine derivatives substituted at position 5 in the thiazolidine nucleus were synthesized and tested against several microorganisms.
4
The compounds are characterized by the presence of protonated diethylaminoalkyloxy side-chains at position 5 or 8.
5
In general, derivatives at position 5 exhibit stronger antiproliferative effects, while the 8 isomers display higher skin phototoxicity.
6
The head was positioned 5 degrees from horizontal before injection.
7
A government spokesman said Eritrean forces attacked Ethiopian positions 5 km from the town of Badme.
8
It is possibly due to different amino acid sequences at positions 5, 10 and 13.
9
Modifications to positions 5 and 4' of the well-known ENR inhibitor triclosan afforded a series of 29 new analogues.
10
The dicycle's wheels are each 9-feet tall and positioned 5-feet apart from one another, set in a steel frame.